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1996-03-09
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Document 0382
DOCN M9650382
TI Probability and characteristics of human immunodeficiency virus
infection in male Greek military personnel with tuberculosis.
DT 9605
AU Bouros D; Panagou P; Tzanakis N; Siafakas N; Department of Thoracic
Medicine, Medical School, University of; Crete, Heraklion, Greece.
SO Respiration. 1995;62(5):280-5. Unique Identifier : AIDSLINE MED/96079419
AB The probability of an AIDS patient being infected with tuberculosis (TB)
has been studied in different populations and found to be increased by
as much as 500 times, but the reverse, i.e. the probability of a patient
with TB being infected with HIV, has not been studied. The aim of this
study was to investigate the hypothesis of greater HIV seropositivity
and altered immune status, as indicated by CD4+ T-lymphocyte counts, in
TB patients. We prospectively studied 162 males, aged 18-30 years,
hospitalized for active, proven TB. Serum for HIV antibodies was tested
twice by ELISA and confirmed by the Western blot technique. The control
group consisted of 145,000 blood donor volunteers serving in the army,
aged 18-30 years. The number of CD4+ T lymphocytes was also measured in
the patients and the control group. We found that the rate of HIV
seropositivity in TB patients was 2.4% (4 of 162), while it was 0.214%
in the control group (p < 0.0001). Using the Bayes' theorem we found
that the probability of a TB patient being infected with HIV was 9.1%,
approximately 150 times higher than the expected rate in the matched
control group (p < 0.0001). The number of CD4+ T lymphocytes was
significantly lower in pulmonary and extrapulmonary TB patients than in
the control group, taking into account the HIV status (p < 0.001). Our
results suggest that there is a 150 times greater probability of a TB
patient being infected with HIV. CD4+ T lymphocytes are significantly
lower in all groups of TB patients.
DE Adolescence Adult AIDS-Related Opportunistic
Infections/*COMPLICATIONS/EPIDEMIOLOGY Bayes Theorem CD4 Lymphocyte
Count Greece/EPIDEMIOLOGY Human HIV
Infections/*COMPLICATIONS/EPIDEMIOLOGY HIV
Seropositivity/*COMPLICATIONS/EPIDEMIOLOGY Male *Military Personnel
Prevalence Prospective Studies
Tuberculosis/*COMPLICATIONS/EPIDEMIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).